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Kazuki Yoshida, MD, MPH, ScD: Methotrexate Access in the Post-Roe v Wade Era

Published: December 1, 2022 Rheumatology Network Read the Full Article >> In the wake of the Supreme Court’s decision to overturn Roe v Wade, results of a recent study indicated that more than half of female patients treated with methotrexate, a commonly-prescribed drug used to manage rheumatic diseases, lived in states with abortion restrictions or[…]

Validation of a machine learning approach to estimate expanded disability status scale scores for multiple sclerosis

Published: June 22, 2022 Sage Journals Read the Full Article >> Background: Disability assessment using the Expanded Disability Status Scale (EDSS) is important to inform treatment decisions and monitor the progression of multiple sclerosis. Yet, EDSS scores are documented infrequently in electronic medical records. Objective: To validate a machine learning model to estimate EDSS scores[…]

Weight gain and comorbidities associated with oral second-generation antipsychotics: analysis of real-world data for patients with schizophrenia or bipolar I disorder

Published: February 14, 2022 BMC Psychiatry Read the Full Article >> Background: Many second-generation antipsychotics (SGAs) are associated with weight gain and cardiometabolic effects. Antipsychotic-associated weight gain is linked to treatment interruptions, potentially increasing risk of relapse and hospitalization. This retrospective study assessed clinically significant weight gain (CSWG), treatment interruptions, and development of cardiometabolic conditions[…]

Real-world evidence analysis of the impact of steroid-eluting implants on healthcare resource use among chronic rhinosinusitis patients undergoing sinus surgery

Published: January 20, 2022 Taylor & Francis Online Read the Full Article >> Objective: To compare healthcare resource use (HCRU) in patients undergoing sinus surgery with or without steroid-eluting sinus implants Methods: A retrospective, observational cohort study using real-world evidence data (OM1, Inc, Boston, MA, USA) was conducted on adult patients with chronic rhinosinusitis (CRS)[…]

Validation of a machine learning approach to estimate Clinical Disease Activity Index Scores for rheumatoid arthritis

Published: October 29, 2021 Read the Full Article >> Objective: Disease activity measures, such as the Clinical Disease Activity Index (CDAI), are important tools for informing treatment decisions and monitoring patient outcomes in rheumatoid arthritis (RA). Yet, documentation of CDAI scores in electronic medical records and other real-world data sources is inconsistent, making it challenging[…]

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